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人们发现,许多类型的恶性肿瘤中,血浆酶原激酶(PA)的活性与正常组织相比有很大变化。在结肠和直肠,这种变化表现为尿型血浆酶原激酶(u-PA)显著增高以及组织型 PA(t-PA)和其他型 PA 减少。人们还发现癌变与癌变前 PA 含量与正常组织也有显著差异,故PA 测定具有诊断和治疗意义。作者通过活检与相应切除标本以及邻近部位活检标本的组织学检查对比,证明 PA 含量测定在胃肠道癌变的内窥镜活检中的实用价值。A 组为14名结直肠癌患者,男5人,女9人,平均年龄69岁。在内窥镜检查后15天进行手术切除。B 组为6名胃腺癌患者,平均年龄59岁。在内窥镜检查后20天进行手术切除。活检及切
It has been found that in many types of malignant tumors, the activity of plasma plasminogen activator (PA) varies greatly from normal tissues. In the colon and rectum, this change is manifested by a significant increase in urinary plasma plasminogen activator (u-PA) and a decrease in tissue PA (t-PA) and other PA types. It has also been found that pre-cancerous and pre-cancerous PA levels are also significantly different from normal tissues, so the PA assay has diagnostic and therapeutic implications. The authors compared the biopsy with the histological examination of the corresponding resected specimen and the biopsy specimen of the adjacent part to prove the practical value of PA determination in endoscopic biopsy of gastrointestinal cancer. In group A, there were 14 patients with colorectal cancer, 5 males and 9 females, with an average age of 69 years. Surgical resection was performed 15 days after endoscopy. Group B was 6 patients with gastric adenocarcinoma, with an average age of 59 years. Surgical resection was performed 20 days after endoscopy. Biopsy and cutting