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目的:检测卵巢上皮性癌组织的synuclein-γ表达情况,结合临床资料进行分析,研究synuclein-γ表达与卵巢癌预后之间的关系。方法:应用免疫组化方法对30例正常卵巢组织石蜡切片,101例上皮性癌组织石蜡切片进行synuclein-γ表达的检测。结果:正常卵巢组织中未见synuclein-γ的表达(0/30),63.4%(64/101)的卵巢癌组织表达synuclein-γ,在减瘤满意的43例患者中,有25例复发。χ2检验提示synuclein-γ的表达与复发有关(58.1%,P=0.038),与腹腔转移有关(P=0.007),而与年龄、绝经与否、绝经年龄、生育年龄、病理类型、肿瘤分期、淋巴结转移等因素均无关。结论:卵巢癌组织中存在synuclein-γ异常高表达,并与卵巢癌的复发转移有关,有可能成为提示卵巢癌复发的指标。
Objective: To detect the expression of synuclein-γ in ovarian epithelial carcinoma and to analyze the relationship between the expression of synuclein-γ and the prognosis of ovarian cancer. Methods: Immunohistochemistry was used to detect the expression of synuclein-γ in paraffin sections of 30 cases of normal ovarian tissue and 101 cases of epithelial carcinoma. Results: The expression of synuclein-γ was not found in normal ovarian tissue (0/30), and the expression of synuclein-γ in 63.4% (64/101) ovarian cancer tissues. Of the 43 patients with satisfactory tumor reduction, 25 relapsed. The χ2 test showed that the expression of synuclein-γ was related to recurrence (58.1%, P = 0.038), which was associated with peritoneal metastasis (P = 0.007), but not related to age, menopause, age at menopause, Lymph node metastasis and other factors have nothing to do. Conclusion: The abnormal expression of synuclein-γ in ovarian cancer tissues is related to the recurrence and metastasis of ovarian cancer, which may be an indicator of the recurrence of ovarian cancer.