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应用流式细胞免疫学方法对 62例长期单纯使用地塞米松 ( DXS)和复方氨基比林 ( AMC)退热儿童进行 T淋巴细胞亚群、B淋巴细胞及活化 B淋巴细胞检测。结果表明 :此类儿童的 T细胞总数明显降低 ( P<0 .0 5) ,尤以 CD4 下降明显 ( P<0 .0 1) ,CD8细胞数轻度下降 ( P>0 .0 5) ,B淋巴细胞及活化 B淋巴细胞数明显下降 ( P<0 .0 5)。本文提示 ,长期单纯使用 DXS及 AMC退热可致儿童免疫功能明显下降 ,且与使用次数及时间呈正相关。
Flow cytometry was used to detect T lymphocyte subsets, B lymphocytes and activated B lymphocytes in 62 long-term dexamethasone (DXS) and compound aminopyrine (AMC) antipyretic children. The results showed that the total number of T-cells in these children was significantly lower (P <0.05), especially in CD4 (P <0.01), and the number of CD8 was slightly decreased (P> 0.05) B lymphocytes and activated B lymphocytes decreased significantly (P <0.05). This paper suggests that long-term simple use of DXS and AMC fever can cause children’s immune function decreased significantly, and with the number of times and the use of time was positively correlated.