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缺血再灌注损伤是各种器官及组织移植过程中导致早期失去功能的最主要原因。近年来,越来越多的研究证实,细胞凋亡是造成移植物缺血再灌注损伤早期细胞死亡的主要方式。现将缺血再灌注损伤时细胞凋亡及相关基因B-细胞淋巴瘤/白血病-2原癌基因(B-celllymphoma/leukemia-2,Bcl-2)以及其调控机制的相关研究进展综述如下。
Ischemia-reperfusion injury is the leading cause of early loss of function in various organ and tissue transplantation processes. In recent years, more and more studies confirm that apoptosis is the main way to cause cell death in the early stage of graft ischemia-reperfusion injury. The related research progress of apoptosis and related gene B-cell lymphoma / leukemia-2 (Bcl-2) and their regulatory mechanisms during ischemia-reperfusion injury are summarized as follows.