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目的:观察参芪扶正注射液联合三参芪口服液对宫颈癌术后放疗患者T淋巴细胞亚群、自然杀伤细胞(NK)细胞及Th1/Th2细胞的影响。方法:将78例患者随机按数字表法分为观察组和对照组各39例。对照组患者进行广泛性全子宫切除术,术后给予患者放化疗,钴60机全盆外照射5 000 CGy/25次,共5周;铱192腔内照射“A”点,600~700 CGy次/周,共4周。观察组在对照组治疗的基础上加用参芪扶正注射液,250 m L/次,静脉滴注,连续21 d为1个疗程,休息7 d后再继续下1个疗程,连续使用3个疗程。三参芪口服液,20 m L/次,2次/d,连续使用12周。两组疗程均为12周。检测治疗前后外周血T淋巴细胞亚群(CD3+,CD4+,CD8+和CD4+/CD8+)和NK水平;检测治疗前后干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)水平;进行治疗前后生活质量(KPS)评分。结果:治疗后观察组CD3+,CD4+,CD4+/CD8+和NK细胞水平较治疗前上升(P<0.01),并高于对照组(P<0.01),CD8+水平较治疗前下降(P<0.01),并低于对照组(P<0.01);治疗后观察组IFN-γ和IL-2水平高于对照组(P<0.01);观察组IL-4,IL-6和IL-10水平低于对照组(P<0.01);治疗后观察组KPS评分为(76.4±7.6),对照组为(70.5±6.8),观察组高于对照组(P<0.01);观察组生活质量评价有效率为87.2%高于对照组的64.1%(P<0.05)。结论:参芪扶正注射液联合三参芪口服液能提高宫颈癌术后放化疗患者的生存质量,改善患者免疫功能,对宫颈癌治疗具有一定的优势。
Objective: To observe the effect of Shenqi Fuzheng injection combined with San Shen Qi oral liquid on T lymphocyte subsets, natural killer (NK) cells and Th1 / Th2 cells in patients with cervical cancer after radiotherapy. Methods: 78 patients were randomly divided into observation group and control group according to the digital table method in 39 cases. The patients in the control group underwent radical hysterectomy. The patients were given radiotherapy and chemotherapy after the operation, and the radiotherapy and chemotherapy of the cobalt 60 machine was performed 5 000 CGy / 25 times for 5 weeks. Irradiation was performed at 192 A / 700 CGy times / week for 4 weeks. The observation group was treated with Shenqi Fuzheng injection at the dose of 250 m L / times for 21 days for 1 course of treatment and 7 days of rest for 1 course of treatment. Three consecutive treatments Course of treatment. San Shen Qi oral solution, 20 m L / time, 2 times / d, continuous use for 12 weeks. The two groups were treated for 12 weeks. Peripheral blood T lymphocyte subsets (CD3 +, CD4 +, CD8 + and CD4 + / CD8 +) and NK levels were measured before and after treatment. The levels of IFN-γ, IL-2 and leukocyte (IL-4), interleukin-6 (IL-6) and interleukin-10 (IL-10) levels were measured before and after treatment. Quality of Life (KPS) scores were measured before and after treatment. Results: After treatment, the levels of CD3 +, CD4 +, CD4 + / CD8 + and NK cells in the observation group increased significantly (P <0.01) and were higher than those in the control group (P <0.01) The levels of IL-4, IL-6 and IL-10 in the observation group were lower than those in the control group (P <0.01). The levels of IFN-γ and IL-2 in the observation group were higher than those in the control group (P <0.01). After treatment, the KPS score of the observation group was (76.4 ± 7.6) and that of the control group (70.5 ± 6.8), and the observation group was higher than that of the control group (P <0.01); the effective rate of the observation group was 87.2 % Higher than 64.1% of the control group (P <0.05). Conclusion: Shenqi Fuzheng injection combined with San Shen Qi Oral Liquid can improve the quality of life of patients with cervical cancer after radiotherapy and chemotherapy, and improve the immune function of patients with cervical cancer treatment has some advantages.