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本实验观察了三种应激情况下,大鼠血浆、下丘脑、延髓、心肌、血管及肾上腺组织血管紧张素Ⅱ(AⅡ)含量,以及血浆皮质酮含量的变化。应激方式分为急性应激(冷水游泳、断肢创伤)与慢性应激(寒冷环境刺激)。结果表明:急性应激动物血中AⅡ剧烈增高,游泳组达对照值的900％,创伤组增至390％,慢性寒冷组增至134％;而组织AⅡ除肾上腺外,则以慢性寒冷组增加最明显,游泳组次之,创伤组无明显变化。血浆皮质酮各组均显著增高,分别达对照组的380％,382％,250％。作者认为循环AⅡ与组织AⅡ含量的变化,可能分别在急性与慢性应激过程中发挥重要的作用,似应列入应激激素。
In this study, we observed the changes of plasma angiotensin Ⅱ (AⅡ) and corticosterone in plasma, hypothalamus, medulla oblongata, myocardium, blood vessels and adrenal glands of rats under three stress conditions. Mode of stress is divided into acute stress (cold water swimming, limb injury) and chronic stress (cold environment stimulation). The results showed that the AⅡ level in acute stress animals increased dramatically, reaching 900% in swimming group, 390% in wound group and 134% in chronic cold group, while that in chronic cold group increased Most obviously, the swimming group followed by the trauma group did not change significantly. Plasma corticosterone in all groups were significantly higher, respectively, 380%, 382%, 250% of the control group. The authors believe that changes in the content of circulating A Ⅱ and tissue A Ⅱ may play an important role in the process of acute and chronic stress, respectively, and should be included in stress hormones.