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目的：探讨幽门螺杆菌（ Ｈ Ｐ）感染对胃粘膜上皮细胞凋亡的影响，揭示 Ｈ Ｐ与胃癌的关系。方法：利用 Ｄ Ｎ Ａ 缺口末端标记技术对正常胃粘膜、 Ｈ Ｐ阳性和 Ｈ Ｐ阴性胃良性病变及胃癌等１３０ 例活检组织进行细胞凋亡状态的研究。结果： Ｈ Ｐ阳性浅表性胃炎和萎缩性胃炎的凋亡指数明显增加，而 Ｈ Ｐ阳性异型增生和胃癌的凋亡指数降低；从浅表性胃炎到胃癌， Ｈ Ｐ阳性组的凋亡指数明显递减。结论：从浅表性胃炎到胃癌形成的过程中， Ｈ Ｐ可能在前期诱导细胞凋亡，而后期呈现抑制细胞凋亡的倾向。
Objective: To investigate the effect of Helicobacter pylori (Hp) infection on gastric mucosal epithelial cell apoptosis and to reveal the relationship between H P and gastric cancer. Methods: The apoptosis of 130 biopsies including normal gastric mucosa, H P positive and H P negative gastric benign lesions and gastric cancer were studied by D N A nick end labeling. Results: The apoptosis index of H P -positive superficial gastritis and atrophic gastritis increased significantly, but the H P-positive dysplasia and gastric cancer apoptosis index decreased. From superficial gastritis to gastric cancer, the apoptosis index of H P positive group Obviously diminished. Conclusion: From the superficial gastritis to the formation of gastric cancer, H P may induce cell apoptosis in the early stage and inhibit the apoptosis in the late stage.