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作者用口服8-甲氧基补骨脂素(8-MOP)及长波紫外线照射(UVA)治疗不同期的蕈样肉芽肿(MF)38例。其诊断都经过组织病理学证实。其中24例为男性,14例为女性。临床病期见下表: 大部分患者开始用UVA的量为1.5～2.5焦耳/平方厘米,以后根据患者的反应逐渐增量。照射前2小时口服8-MOP,每公斤体重为0.6毫克。治疗结果如下:第一期7例,皮损消失者7例,大部分在治疗10周之内完全消失。平均维持量为5焦耳/平方厘米,多数(5例)每周治疗1次。数例维持治疗1年以上,保持无症状。第二期17例,有14例损害完全消失。1例无变化,1例加剧,1例死亡。平均
The authors treated 38 cases of mycosis fungoides (MF) with different doses of oral 8-methoxypsoralen (8-MOP) and long-wave ultraviolet (UVA) irradiation. The diagnosis was confirmed by histopathology. Of these, 24 were male and 14 were female. The clinical stage is shown in the following table: The majority of patients started with UVA in an amount of 1.5 to 2.5 Joules/cm2, which was gradually increased according to the patient’s response. Oral 8-MOP 2 hours before irradiation, 0.6 mg/kg body weight. The results of the treatment were as follows: 7 cases in the first phase and 7 cases in which skin lesions disappeared. Most of them disappeared within 10 weeks of treatment. The average maintenance dose was 5 Joules/cm2, with the majority (5 cases) treated once a week. Several cases were maintained for more than one year and remained asymptomatic. In the second phase of 17 cases, 14 cases completely disappeared. One case did not change, 1 case increased, and 1 case died. average