早在十九世纪就已发现锂盐是一种良好的镇静与抗惊厥药,并开始用来治疗躁狂症与其它精神病患者。至1950年,有人注意到口服锂盐能使血液白细胞计数升高,一般在10,000～14,000间,少数高达20,000以上。两年后,进一步发现这种白细胞数的升高,主要是中性粒细胞增高的结果,并常伴有淋巴细胞减少的倾向。一旦停药,血象可望复原。 As early as the 19th century, lithium salt was found to be a good sedative and anticonvulsant drug and was initially used to treat mania and other psychiatric disorders. By 1950, it was noted that oral lithium salt can make blood leukocyte count increased, usually in 10,000 to 14,000, a few up to 20,000 or more. Two years later, it was further found that this increase in the number of white blood cells, mainly as a result of increased neutrophils, and often accompanied by lymphocytopenia. Once the withdrawal, the blood is expected to recover.