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目的 :探讨雷公藤多苷在治疗儿童肾病综合征中的作用及其机制。 方法 :对 16年来在我科住院明确病理类型的 5 5 0例中 10 5例肾病综合征患儿 ,在激素逐渐减量的同时用雷公藤多苷 ( 1m g/ kg· d- 1 )治疗。 结果 :81例肾病综合征获得缓解 ,总缓解率达 77.1% ,其中 MCNS( 2 4例 )、Ms PGN ( 46例 )、MPGN ( 17例 )、MN ( 13例 )和FSGS( 5例 )的缓解率分别为 91.7%、89.1%、76 .5 %、38.5 %和 0 % ,FSGS效果最差 ;14例改善 ,10例无效。 结论 :由于病理类型不同疗效相差较大 ,临床上对激素治疗无效或耐药的肾病综合征患儿 ,应及时行肾活检以明确病理诊断 ,对病理类型为 MCNS和 Ms PGN者可单用雷公藤多苷治疗 ,以避免长期应用激素的不良反应 ,这是治疗儿童肾病综合征的有效方法之一
Objective: To investigate the effect and mechanism of tripterygium glycosides in children with nephrotic syndrome. Methods: A total of 105 cases of nephrotic syndrome were enrolled in 550 cases of definite pathological type hospitalized in our department over the past 16 years. Treatment with tripterygium glycosides (1 m g / kg · d-1) . Results: The nephrotic syndrome was relieved in 81 cases with a total response rate of 77.1%. Among them, MCNS (24 cases), Ms PGN (46 cases), MPGN (17 cases), MN (13 cases) and FSGS The rates of remission were 91.7%, 89.1%, 76.5%, 38.5% and 0%, respectively. FSGS had the worst effect; 14 cases were improved and 10 cases were ineffective. Conclusion: Due to the different pathological types of different effects of large clinical clinically ineffective or resistant hormone therapy in children with nephrotic syndrome, renal biopsy should be promptly clear pathological diagnosis of the pathological types of MCNS and Ms PGN were alone Thunder Treatment of stoutoglycosides to avoid adverse effects of long-term use of hormones is one of the effective ways to treat childhood nephrotic syndrome