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目的观察重组人表皮生因子(rhEGF)对眼表上皮修复的影响及羊膜移植治疗翼状肉的疗效。方法对36例患者40眼的翼状肉施行肉切除－羊膜移植术,术后随机分为(rhEF治疗组(20眼)和药物赋型剂对照组(20眼),分别观察两组角膜上皮愈合速度和结膜上皮覆盖羊膜植片的愈合速度,对全部患者随访3-12个月。结果rhEGF治疗组术后角膜上皮愈合速度[(74983±1998)μm/h]显著高于对照组[(59372±17.197)μm/hP＜0.01];rhEGF治疗组结膜上皮愈合速度[(36.584±7.888)μm/h显著高于对照组[(29．181±5.450) μmh,P＜0.01]。随访全部病例未见复发,结论rhEGF可有效促进眼表上皮的损伤修复,羊膜移植为治疗翼状肉的较好方法。
Objective To observe the effect of recombinant human epidermal growth factor (rhEGF) on the repair of ocular surface epithelium and the effect of amniotic membrane transplantation for the treatment of pterygium. Methods Twenty - six eyes of 40 patients with pterygium underwent resection - amniotic membrane transplantation and were randomly divided into rhEF treatment group (20 eyes) and drug excipient control group (20 eyes). The corneal epithelial healing Speed and healing rate of amniotic membrane covered by conjunctival epithelium were all followed up for 3-12 months.Results The healing rate of corneal epithelium [(74983 ± 1998) μm / h] in rhEGF treatment group was significantly higher than that in control group [(59372 ± 17.197) μm / hP <0.01]. The healing rate of conjunctival epithelium in rhEGF treated group [(36.584 ± 7.888) μm / h was significantly higher than that in control group [(29.181 ± 5.450) μmh, P <0.01] See recurrence, Conclusion rhEGF can effectively promote the repair of ocular surface epithelial injury, amniotic membrane transplantation for the treatment of pterygium, a better way.