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FTY720(2-amino-2-[2-(4-octylphenyl)ethyl]-l,3-propanediol hydrochloride,图1)是日本京都大学的藤多哲朗教授等从寄生蝉幼虫的子囊菌(Isariasinclairii)培养液中提取的抗生素成分。ISP-1(myriocin/thermozymocidin)是经化学结构修饰后得到的合成药物[1],在细胞内被鞘氨醇激酶2(sphingosinekinase 2,Sphk2)磷酸化为具有生物活性的FTY720-P。
FTY720 (2-amino-2- [2- (4-octylphenyl) ethyl] -l, 3-propanediol hydrochloride, FIG. 1) was cultured from Isarias incana larvae of Asarias sinensis Antibiotic composition extracted from the liquid. ISP-1 (myriocin / thermozymocidin) is a synthetic drug that has been chemically modified [1] and is phosphorylated into biologically active FTY720-P intracellularly by sphingosinekinase 2 (Sphk2).