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目的:观察参附注射液联合丹参川芎嗪注射液治疗慢性心力衰竭(CHF)的临床疗效。方法:将60例CHF患者随机分为2组各30例,均以常规西医基础治疗,治疗组加用参附注射液联合丹参川芎嗪注射液静脉滴注。2组均治疗2周。观察临床症状体征,记录多普勒超声心动图测定每搏输出量(SV)、左室射血分数(LVEF)、左室舒张末期内径(LVED)、左室收缩末期内径(LVSD),6min步行距离等。结果:总有效率治疗组为93.3%,对照组为76.7%,2组总有效率比较,差异有显著性意义(P<0.05),治疗组疗效优于对照组。2组治疗前后SV、LVEF、LVSD、LVED分别比较,差异均有显著性意义(P<0.05),治疗后2组间比较,治疗组在改变以上指标方面优于对照组(P<0.05)。2组治疗后6min步行距离与治疗前比较,差异均有显著性意义(P<0.05)。治疗后2组间比较,治疗组在增加6min步行距离方面优于对照组(P<0.05)。结论:参附注射液联合丹参川芎嗪注射液治疗CHF疗效较好。
Objective: To observe the clinical effect of Shenfu injection combined with injection of Salviae miltiorrhizae ligustrazine on chronic heart failure (CHF). Methods: Sixty patients with CHF were randomly divided into two groups of 30 cases. All patients were treated with conventional western medicine. The treatment group was treated with Shenfu injection combined with Ligustrazine and ligustrazine injection. 2 groups were treated for 2 weeks. The symptoms and signs were observed and the stroke volume (SV), left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVED), left ventricular end-systolic diameter (LVSD) and 6min walk were recorded by Doppler echocardiography Distance and so on. Results: The total effective rate was 93.3% in the treatment group and 76.7% in the control group. There was significant difference between the two groups in total effective rate (P <0.05). The curative effect in the treatment group was better than that in the control group. There were significant differences in SV, LVEF, LVSD and LVED between the two groups before and after treatment (P <0.05). After treatment, the treatment group was better than the control group in changing the above indexes (P <0.05). The walking distance of 6 minutes after treatment in both groups was significantly different from that before treatment (P <0.05). After treatment, the two groups were better than the control group (P <0.05) in increasing 6-minute walk distance. Conclusion: Shenfu injection combined with injection of Salvia miltiorrhizae ligustrazine treatment of CHF better.