1病历资料患者男,37岁,出租车司机。主因双手皮肤变紧变硬2年余,皮肤紫癜1年余,加重2个月于2007-09-26入院。于2年前无明显诱因出现双手皮肤变紧变硬,不易捏起,伴有雷诺现象。1年前反复出现双下肢皮肤紫癜,查血常规提示PLT80×109/L,未予诊治。2个月前症状加重,伴有低热、头昏? Patient information Male patient, 37 years old, taxi driver. Mainly due to two hands tighten the skin harden more than 2 years, more than 1 year of skin purpura, increased 2 months in 2007-09-26 admission. 2 years ago, there was no obvious incentive to appear hands tight and hardened skin, difficult to pinch, with Renault phenomenon. A year ago, double skin purpura repeatedly appear, check the blood routine prompted PLT80 × 109 / L, no diagnosis and treatment. 2 months ago, the symptoms worsened, accompanied by fever, dizziness?