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急性心肌梗塞可从测出坏死心肌释放的各种酶和肌红蛋白而加以判定。本文报道用放射免疫法测定心肌纤维结构的成份一心肌肌凝蛋白轻链I(LCI)以诊断心肌梗塞和观察梗塞的范围。方法和结果:24例急性心肌梗塞患者在梗塞3天内,每3～6小时采血一次,3～7天内每日采血一次进行 LCI 放射免疫法测定。结果表明,LCI 在急性心肌梗塞发作4小时后、16小时内即开始上升,30～144小时(90.1±34.2小时)后达最高值(35.0±14.1毫微克/毫升),高值可持续7～16天。血中LCI 变化的曲线除1例呈双相性外,其余大致为单相性。24例中前壁梗塞为11例,在 V_1-V_3出现异常 Q 波者有3例,其 LCI 最高值平均为18毫微克/毫升,在Ⅰ及 V_1-V_5出现异常 Q 波者有5例,LCI最高值平均为45.2±10.6毫微克/毫升。由此可见,
Acute myocardial infarction can be determined from various enzymes and myoglobin released from necrotic myocardium. This article reports the use of a radioimmunoassay for the determination of myocardial myosin light chain I (LCI) as a component of myocardial fibrosis to diagnose myocardial infarction and to determine the extent of the infarct. Methods and Results: Twenty-four patients with acute myocardial infarction received blood sampling once every 3 to 6 hours within 3 days after infarction and once daily for 3 to 7 days for LCI radioimmunoassay. The results showed that the LCI began to rise within 16 hours after onset of acute myocardial infarction (4 hours), reaching the highest value (35.0 ± 14.1 ng / ml) after 30 to 144 hours (90.1 ± 34.2 hours) 16 days. Blood LCI changes in the curve except 1 case was biphasic, the rest is roughly monophasic. There were 11 cases of anterior wall infarction in 24 cases, 3 cases of abnormal Q wave in V_1-V_3, the highest value of LCI was 18 ng / ml in average, 5 cases of abnormal Q wave in Ⅰ and V_1-V_5, The highest LCI value averaged 45.2 ± 10.6 ng / mL. Thus,