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目的 :观察中药复方植物胰岛素 (CPI)对糖尿病大鼠肾血管重建的影响 ,并探讨糖尿病时肾血管重建的方式和机制。方法 :以链脲佐菌素 (STZ)诱导 SD大鼠建立糖尿病动物模型 ,应用形态学、计算机图像分析等方法 ,观察糖尿病大鼠肾内小动脉和肾小球毛细血管基底膜的几何形态 ,以及 CPI和氨基胍对其的影响。结果 :肾内小动脉表现为壁厚、壁面积增大 ,壁腔比 (壁厚内径比、壁面积内径比 )增大 ;肾毛细血管基底膜增厚。CPI和氨基胍均可有效地抑制糖尿病肾内小动脉和肾毛细血管的重建 ,两者效果无明显差异 (P>0 .0 5 )。 结论 :肾内小动脉病变是导致糖尿病肾病的原因之一 ;CPI能有效地抑制肾血管的重建。
Objective: To observe the effect of Chinese compound herbal insulin (CPI) on renal vascular remodeling in diabetic rats, and to explore the methods and mechanisms of renal revascularization during diabetes. METHODS: SD rats were induced to establish diabetic animal model by streptozotocin (STZ). Morphological and computer image analysis methods were used to observe the geometry of the renal arterioles and glomerular basement membranes in diabetic rats. And the effect of CPI and aminoguanidine on it. Results: Intrarenal arterioles showed increased wall thickness and wall area, wall-to-lumen ratio (ratio of wall-to-thickness inner diameter, ratio of wall area to inner diameter), and thickening of basement membrane of renal capillaries. Both CPI and aminoguanidine could effectively inhibit the reconstruction of renal arterioles and renal capillaries in diabetic kidneys, and there was no significant difference between the two effects (P>0.05). Conclusion : Intrarenal arteriopathy is one of the causes of diabetic nephropathy; CPI can effectively inhibit the reconstruction of renal vasculature.