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动脉粥样硬化是心脑血管疾病最为重要的病变基础,不稳定斑块的破裂形成栓子可直接导致急性、严重性的心脑血管疾病事件~([1-2])。因此,使用有效的实验室检查及影像学检查手段早期筛查出患者的不稳定动脉粥样硬化斑块具有重大意义。继Bayes-Genis A等~([3])在2001年提出妊娠相关蛋白A(pregnancy-associated plasma protein-A,PAPP-A)是不稳定动脉粥样硬化斑块和急性冠脉综合征的标记物后关于PAPP-A调控动脉粥样硬化进展的机制以及其对急性心脑
Atherosclerosis is the most important pathological basis of cardiovascular and cerebrovascular diseases. The rupture of unstable plaque can lead to acute and serious cardiovascular and cerebrovascular diseases directly. ([1-2]). Therefore, the use of effective laboratory tests and imaging tests to screen for patients with unstable atherosclerotic plaque is of great significance. Following Bayes-Genis A et al. ([3]) proposed in 2001 that pregnancy-associated plasma protein-A (PAPP-A) is a marker of unstable atherosclerotic plaque and acute coronary syndrome The mechanism behind PAPP-A regulation of atherosclerosis and its effect on acute cardiocerebellar