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目的:观察胰岛素联合百令胶囊治疗早期糖尿病肾病患者的临床疗效,并探讨其可能机制。方法:收集在我院就诊或住院治疗的62例糖尿名肾病患者,随机分为实验组和对照组,每组31例。对照组患者给予诺和灵30R胰岛素,实验组患者在对照组基础上给予百令胶囊治疗。治疗后,对患者的血肌酐、尿蛋白、CD68以及临床疗效进行检测并比较。结果:与治疗前相比,两组患者治疗后的血肌酐、尿蛋白、CD68均下降(P<0.05);与对照组相比,实验组患者的血肌酐、尿蛋白、CD68水平较低(P<0.05),临床治疗有效率较高(P<0.05)。结论:胰岛素联合百令胶囊能够有效提高早期糖尿病肾病患者的临床疗效,可能与其降低血清CD68水平,减轻炎症反应有关。
Objective: To observe the clinical efficacy of insulin combined with Bailing capsule in treating patients with early diabetic nephropathy and to explore its possible mechanism. Methods: 62 patients with diabetic nephropathy who were treated in our hospital or hospitalized were randomly divided into experimental group and control group, with 31 cases in each group. Patients in the control group were given Novolin 30R insulin. Patients in the experimental group were treated with Bailing capsule on the basis of the control group. After treatment, the patient’s serum creatinine, urinary protein, CD68 and clinical efficacy were detected and compared. Results: Compared with the control group, the serum creatinine, urine protein and CD68 decreased after treatment in both groups (P <0.05). Compared with the control group, the serum creatinine, urinary protein and CD68 in the experimental group were lower P <0.05), clinical treatment is more effective (P <0.05). Conclusion: Insulin combined with Bailing capsule can effectively improve the clinical efficacy of patients with early diabetic nephropathy, which may be related to its reduction of serum CD68 level and alleviation of inflammatory reaction.