Four Civilized Central Park Zoo animals lion Alex, zebra Marty, giraffe Melman， pregnant hippo Gloria are best friends whom were fostered（养育）by human. But they have different temperaments. And they spent their quiet lives in face mixed people havingin blissful captivity（囚禁）with delicious food and good condition. Though it’s boring, they are accustomed to it because they take such world they have for granted. Until born curiously Marty flees away from the animal zoo flukey（侥幸地）under a group of penguins’（企鹅）help, their quiet lives are break up finally.
　　纽约中央公园动物园中，狮子亚力克斯、斑马玛蒂、长颈鹿梅尔曼、河马格洛莉娅是一群从小被人类养大的好伙伴，他们的脾气禀性各不相同，在设施先进、食物可口的安逸的圈养条件下，面对着形形色色的游人，打发着波澜不惊的岁月。生活虽然很枯燥，但他们确实很习惯，以为自己的世界就应该是眼前的这个样子，直到有一天，生性不甘寂寞的玛蒂在一群好事企鹅的帮助下侥幸地逃出了动物园，四个好伙伴平静的生活终于被打破。
　　Decide to flee away from the zoo to findMarty , but soon they are caught and boxed up to sent free to Africa in subway station by the zoo’s employees. On their way, they get free finally and drift to Madagascar, although there is a peril of the sea. They recognize the lemur（狐猴）and their kingdom there, surely their kingdoms’ enemies too. When the two sides both want gain something from they four, after their curious about the first entering to virgin forest is ending, how could they who are costumed to foster by human in the animal zoo come to adapt with the real law of the jungle wild life?
　　亚力克斯、梅尔曼、格洛莉娅决定逃出动物园寻找玛蒂，但就在脱逃计划成功之后不久，动物园的工作人员在地铁站抓住了他们并将他们装箱准备托运到非洲，然后放生于大自然。运送的路上，虽然发生了海难，几个伙伴终于获得了自由并漂流到了马达加斯加岛，他们认识了当地的狐猴和他们的动物王国，当然还有他们王国的敌对兽群。当这两方面都想从他们四个身上得到某些好处时，在第一次踏入原始森林的好奇过后，已经习惯了动物园被人照顾的他们，又将如何适应这真正的弱肉强食的野生生活？好戏开始了！