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近来一些研究表明胰岛素可增加人、猪和大鼠的卵巢粒层细胞。猪卵巢的卵泡膜细胞合成和分泌的雄激素对粒层细胞合成雌激素起重要作用,胰岛素对卵泡生物合成类固醇的作用和机理用粒层细胞已广泛进行研究,发现猪粒层细胞有胰岛素特异性受体,在猪粒层细胞的培养基中加入胰岛素起促进作用并引起细胞形态特征不同变化和增加类固醇激素的合成率。另外通过培养猪卵泡组织发现胰岛素还可增加黄体生成素(LH)刺激的雄激素的产
Recent studies have shown that insulin can increase ovarian granulosa cells in humans, pigs and rats. Androgen production and secretion by porcine ovarian follicular cells plays an important role in the synthesis of estrogen by granulosa cells. The effect and mechanism of insulin on follicular biosynthesis steroids has been extensively studied with granulosa cells and found that porcine granulosa cells have insulin-specific Sex receptors, in pig granulosa cells in the medium to promote the role of insulin and lead to different changes in cell morphology and increase the rate of steroid hormone synthesis. In addition by the pig follicular tissue culture found that insulin can also increase luteinizing hormone (LH) -stimulated androgen production