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目的 通过对中南大学湘雅医院住院的乳腺癌、良性乳腺病、其他女性恶性肿瘤患者及健康人群尿碘水平进行对比分析,探讨尿碘水平与乳腺癌的关系.方法 选择2018年12月至2019年1月在中南大学湘雅医院住院的初诊乳腺癌患者64例作为病例组,并另选同时期的良性乳腺病组(49例),其他女性恶性肿瘤组(39例),健康体检的成年女性50例作为对照组.采用比色法测定尿碘,将尿碘分为三组:碘过量(＞300 μg/L)、碘适宜(100～300 μ/L)、碘缺乏(＜100 μg/L),并分析尿碘与乳腺癌临床病理的关系 乳腺良性结节组尿碘水平319.13(163.98) μg/L＞乳腺癌组尿碘水平273.96(151.30) μg/L＞女性其他恶性肿瘤组尿碘水平212.95(161.71) μg/L＞正常对照组尿碘水平199.15(194.45) μg/L,各组尿碘水平不全相同(H=9.936,P=0.019),两两组间比较时正常对照组尿碘水平明显低于乳腺良性病组(P=0.013).进一步把尿碘分为碘缺乏(＜100 μg/L),碘适宜(100～ 300μg/L)和碘过量(＞300 μg/L)时,正常对照组尿碘＜100 μg/L人数明显多于乳腺癌组(P=0.021).尿碘水平与乳腺癌原发灶大小有关(Z=-2.307,P=0.021),而与是否淋巴结转移、ER、AR、PR、HER-2表达状态无关(P＞0.05).用多元线性回归方法分析尿碘的影响因素,原发灶大小纳入回归方程(R2=0.136,P=0.007).结论 正常对照组尿碘水平显著低于乳腺癌组,尿碘水平与乳腺癌原发灶大小呈负线性相关,而与是否淋巴结转移、ER、AR、PR、HER-2表达状态无关.“,”Objective To explore the relationship between urinary iodine level and breast cancer,we compare urinary iodine excretion levels in patients with breast cancer,benign breast disease,other female malignant tumors and control subjects in Xiangya Hospital of Central South University.Methods From December 2018 to January 2019,64 patients with newly diagnosed breast cancer in Xiangya Hospital of Central South University were selected as case group,benign breast disease group (n =49),other female malignant tumor group (n =39) and health examination group (n =50) as control group.Urinary iodine was determined by colorimetry.According to the urinary iodine level the patients divided into three groups:iodine excess (＞300 μg/L),medium iodine (100-300 μg/L) and iodine deficiency (＜ 100 μg/L).The relationship between urinary iodine and clinicopathology of breast cancer was analyzed.Results The level of urinary iodine in benign breast nodule group 319.13 (163.98) μg/L ＞ breast cancer group 273.96 (151.30) μg/L ＞ female other malignant tumor group 212.95 (161.71) μg/L ＞ normal control group 199.15 (194.45) μg/L,with significantly differance (H =9.936,P =0.019).Urinary iodine level in the normal control group was significantly lower than that in the benign breast disease group (P =0.013).The patients were further divided into three groups according to the urinary iodine level:iodine excess,iodine medium and iodine deficiency,the number of urine iodine ＜ 100 μg/L in the normal control group was significantly higher than that in the breast cancer group (P =0.021).The level of urinary iodine was negatively correlated with the size of the primary focus of breast cancer (Z =-2.307,P =0.021).The effect of urinary iodine was analyzed by multiple linear regression method.The size of primary focus was included in the regression equation (R2 =0.136,P=0.007),but had nothing to do with lymph node metastasis and the expression status of estrogen receptor (ER),androgen receptor (AR),progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2).Conclusions There is a negative linear correlation between urinary iodine level and the size of primary focus of breast cancer,but it has nothing to do with lymph node metastasis and the expression of ER,AR,PR and HER-2.