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酮康唑,一种口服的咪唑衍生物杀真菌剂,当剂量高于足以对抗真菌活性时,该药通过阻断几种细胞色素P_(450)酶,干扰性腺类固醇和肾上腺类固醇的合成。由于其干扰肾上腺皮质的11β-羟化酶和胆固醇侧链裂解酶的活性,该药是一种有效的皮质醇
Ketoconazole, an oral imidazole derivative fungicide that interferes with the synthesis of gonadal and adrenal steroids by blocking several cytochrome P-450 enzymes at doses higher than enough to combat fungal activity. The drug is a potent cortisol because of its activity in interfering with the 11beta-hydroxylase and cholesterol side-chain lyase in the adrenal cortex