论文部分内容阅读
研究中药参芪脑保颗粒对大鼠局灶脑梗死的疗效。方法 采用光化学法制成大鼠局灶脑缺血模型 ,随机分为对照组、参芪脑保颗粒大、中、小剂量组、溶栓胶囊治疗组、金纳多片治疗组 ,分别于光照后 3h、1、2、3、4d给予灌胃治疗 ,并观察各组大鼠的体重及神经功能评分变化。第 5d处死 ,用TTC及HE染色观察梗死灶体积及病理改变。结果 参芪脑保颗粒治疗组的体重恢复较对照组及金纳多组快 ,大、中剂量组的梗死灶体积明显小于对照组 (P <0 .0 0 1)及金纳多治疗组 (P <0 .0 5 ) ,大剂量组的梗死灶体积小于小剂量组 (P <0 .0 5 ) ,与溶栓胶囊治疗组相比差别不显著 (P >0 .0 5 )。参芪脑保颗粒治疗组神经元缺血性损伤较对照组及金纳多组轻。结论 参芪脑保颗粒对大鼠局灶脑梗死有治疗作用
To study the curative effect of Shenqi Naobao granule on focal cerebral infarction in rats. Methods The model of focal cerebral ischemia in rats was made by photochemical method and randomly divided into control group, Shenqi Naobao Granule large, medium and small dose group, thrombolytic capsule treatment group and Jinnao multiplate treatment group, 3h, 1,2,3,4d given intragastric administration, and observed the changes of body weight and neurological function scores of rats in each group. The rats were sacrificed on the 5th day, and the infarct size and pathological changes were observed by TTC and HE staining. Results The weight recovery of Shenqi Naobao Granules treatment group was faster than that of the control group and the Ginaton group. The volumes of infarction in the large and medium dose groups were significantly smaller than those in the control group (P <0.01) and the Ginaton treatment group P <0.05). The volume of infarction in high-dose group was smaller than that in low-dose group (P <0.05), and there was no significant difference between the two groups (P> 0.05). Shenqi Naobao Granule treatment group than the control group and ischemic neuron injury more light. Conclusion Shenqi Naobao Granule has a therapeutic effect on focal cerebral infarction in rats