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背景:出血性休克和外伤病人复苏一般选用胶体血浆扩容液替代血液成分,其中羟乙基淀粉也用作低温保存剂,运用这些双重性用于血液保存系统,可使红细胞直接输注。羟乙基淀粉在血管内长时间的持续存在说明了吞噬清除系统受到了伤害,羟乙基淀粉的存在恶化了输血导致的免疫调节。设计与方法:检测胶体复苏液对正常外周血多型核细胞和单核细胞的活化反应及吞噬功能的影响。为了模拟低温保护剂相关的溶血,研究了1％和5％红细胞溶解产物的影响。在所有的研究中均用了
Background: Hemorrhagic shock and trauma patients generally choose colloid plasma volume expansion fluid replacement blood components, including hydroxyethyl starch is also used as cryogenic preservatives, the use of these duality for the blood preservation system, allowing the red blood cells directly infusion. The prolonged persistence of hydroxyethyl starch in the blood vessels indicates that the phagocytosis system has been compromised, and the presence of hydroxyethylstarch aggravates immune regulation resulting from blood transfusions. DESIGN AND METHODS: The effects of colloid resuscitation fluid on the activation reaction and phagocytosis of normal peripheral blood mononuclear cells and monocytes were examined. To simulate hypothermia-related hemolysis, the effects of 1% and 5% erythrocyte lysate were studied. Used in all studies