p16基因是新近发现的抑癌基因,定位于人类染色体9p21区,所编码的核磷酸蛋白p16为细胞周期蛋白D/CDK激酶的抑制因子。参与对正常细胞周期演进的调控,防止细胞增生。已发现在大多数恶性肿瘤中有p16基因的缺失或突变,说明p16基因的失活与肿瘤的发生、发展及恶化有极为密切的关系。 The newly discovered tumor suppressor gene p16 is located on the 9p21 region of human chromosome. The encoded p16 gene is an inhibitor of cyclin D / CDK kinase. Participate in the regulation of the normal cell cycle evolution to prevent cell proliferation. It has been found that there is p16 gene deletion or mutation in most malignant tumors, indicating that the inactivation of p16 gene is closely related to the occurrence, development and deterioration of tumors.