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小剂量阿糖胞苷(Ara-c)在体内和体外能诱导白血病细胞分化。本文用 Ara-C20mg,皮下注射一日二次,15～21天为一疗程治疗25例急性白血病。12例完全缓解(48%),9例部分缓解(36%),总缓解率为84%。急性淋巴细胞白血病和急性非淋巴细胞白血病的完全缓解率分别为53.8%和41.7%。无严重并发症和药物副作用。有3例在完全缓解前有明显骨髓抑制,似可支持小剂量 Ara-C 有细胞毒和诱导分化双重作用。
Low-dose cytarabine (Ara-c) induces leukemic cell differentiation in vitro and in vivo. In this paper, Ara-C20mg, subcutaneous injection twice a day, 15 to 21 days for the treatment of 25 cases of acute leukemia. 12 cases were completely relieved (48%), 9 cases partially relieved (36%), and the total remission rate was 84%. The complete remission rates of acute lymphoblastic leukemia and acute non-lymphocytic leukemia were 53.8% and 41.7%, respectively. No serious complications and drug side effects. Three patients had obvious myelosuppression before complete remission. It seems to support the dual action of low dose Ara-C on cytotoxicity and differentiation.