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达到最佳疗效的剂量,病人间有很大的差异。大多数药物的常用剂量,对某些病人可能疗效甚微,而对另一些人则导致严重中毒,完全满意者不多。有时标准给药方案对一些病人不能发挥足够程度的药理效果,往往就误认为这些药无效。值得指出:药物治疗中经常出现的严重不良反应,半数以上是因剂量过高所致。若调节剂量到适合每个病人的要求,用药就可更为安全有效。最佳疗效剂量的确定,可借助于血清药物浓度的测定,从而有助于解释一种药物在常用量下不能产生疗效或产生意外的毒性的原由,这种
To achieve the best effect of the dose, there are great differences between patients. Commonly used doses of most drugs may have little effect on some patients, others cause severe poisoning and are not entirely satisfied. Sometimes the standard dosing regimen does not work to the full extent of the pharmacological effect of some patients and often misses the ineffectiveness of these medications. It is worth pointing out that more than half of the serious adverse reactions that often occur in medical treatment are due to overdosage. Medication can be safer and more effective if adjusted to suit the needs of each patient. The determination of the best therapeutic dose can be made with the aid of serum drug concentration to help explain why a drug does not produce efficacy or unexpected toxicities at the usual doses.