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目的观察咽喉清口含片的抗炎镇痛效应。方法二甲苯诱发小鼠耳廓炎症模型观察咽喉清口含片的抗炎效应,热板法和热水缩尾法疼痛模型观察咽喉清口含片的镇痛效应。结果咽喉清口含片对二甲苯所致的小鼠耳廓肿胀及耳廓毛细血管通透性增加具有显著抑制作用(P<0.01),可延长热板所致小鼠舔后足反应的潜伏期(P<0.05)及热水所致小鼠缩尾潜伏期(P<0.05)。结论咽喉清口含片具有明显的抗炎镇痛作用。
Objective To observe the anti-inflammatory and analgesic effect of the throat QingKao lozenge. Methods Xylene-induced mouse auricle inflammation model was used to observe the anti-inflammatory effect of throat and laryngeal lozenges. The analgesic effect of throat and laryngeal lozenges was observed with the hot plate method and the hot-water tapping method. Results Throat cleavage tablets had a significant inhibitory effect on swelling of ear auricles and increase of capillary permeability of auricles caused by xylene (P <0.01), prolonging the incubation period of licking and hind paw responses induced by hot plate in mice (P <0.05), and the latent period of tail-tail induced by hot water (P <0.05). Conclusion Throat Clearing the mouth tablets have obvious anti-inflammatory analgesic effect.