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目的:观察输血中铁过载对血糖的影响。方法:对比21例铁过载患者的血糖情况,及接受去铁治疗后1、3、6个月的铁蛋白、血糖变化情况,并评价治疗效果。结果:21例铁过载患者中发现高血糖共11例,发生率52.4%,其中8例接受了去铁胺治疗,可评价的有7例,去铁治疗后1个月铁蛋白明显下降,治疗前后比较,差异有统计学意义(P<0.01)。去铁治疗后3个月血糖明显下降,治疗前后比较差异有统计学意义(P<0.05)。治疗后6个月除2例糖尿病仍需胰岛素治疗外,其余5例血糖均恢复正常。2例胰岛素用量较前减少30%。去铁治疗前铁蛋白与血糖高度相关,相关系数r=0.938,双侧Pearson检验P<0.01。结论:铁过载患者高血糖发生率高(52.4%),去铁治疗能有效降低血糖水平,能反应去铁治疗后促进脏器功能恢复的作用,易于评价去铁治疗的效果。
Objective: To observe the effect of iron overload on blood glucose in blood transfusion. Methods: The blood glucose levels of 21 patients with iron overload were compared with those of 1, 3 and 6 months after iron administration, and the therapeutic effect was evaluated. Results: Eleven patients with iron overload were found to have hyperglycemia in 11 cases, with a rate of 52.4%. Among them, 8 received deferoxamine treatment, 7 were evaluable, and the ferritin was significantly decreased 1 month after the treatment. Before and after comparison, the difference was statistically significant (P <0.01). 3 months after deferox treatment, blood glucose was significantly decreased, before and after treatment, the difference was statistically significant (P <0.05). Six months after treatment, except for 2 cases of diabetes still need insulin treatment, the remaining 5 cases of blood glucose returned to normal. 2 cases of insulin dosage decreased by 30%. Ferritin was highly correlated with blood glucose before treatment, with a correlation coefficient of r = 0.938 and a Bilateral Pearson test of P <0.01. CONCLUSION: The incidence of hyperglycemia in patients with iron overload is high (52.4%). Deferox treatment can effectively reduce blood glucose levels and can respond to the effect of deferox treatment on the recovery of organ function. It is easy to evaluate the effect of deferox treatment.