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目的 探讨癌胚抗原 (CEA)表达在胆囊癌的发生、发展中的作用 ,为该病的临床诊治提供参考指标 .方法 应用免疫组织化学 ABC方法 ,对 30例胆囊癌组织标本进行癌胚抗原及增殖细胞核抗原 (PCNA)的检测 .结果 30例胆囊癌组织中 ,1 1例 (36 % )显示 CEA过度表达 ;1 8例 (6 0 % )显示PCNA高表达 ,其中 9例两种标记同时阳性 .半定量分级 ,spearm an秩相关分析两者呈显著相关 (P<0 .0 1 ) ;CEA表达的程度与胆囊癌的组织学类型有关 .结论 胆囊癌中 CEA的异常表达可能有病因学意义 ;CEA的表达情况对反映胆囊癌的生物学特性、衡量胆囊癌分化程度及判断患者预后可能有重要价值
Objective To investigate the role of carcinoembryonic antigen (CEA) expression in the occurrence and development of gallbladder carcinomas and to provide a reference for the clinical diagnosis and treatment of this disease.Methods Immunohistochemical ABC method was used to detect the carcinoembryonic antigen (PCNA) were detected.Results In 30 cases of gallbladder carcinoma, CEA was over-expressed in 11 cases (36%), while PCNA was highly expressed in 18 cases (60%), of which 9 cases were positive for both markers (P <0.01). The degree of CEA expression was correlated with the histological type of gallbladder carcinoma.Conclusion The abnormal expression of CEA in gallbladder carcinoma may have etiological significance ; The expression of CEA may have important value in reflecting the biological characteristics of gallbladder carcinoma, measuring the differentiation of gallbladder carcinoma and judging the prognosis of patients