论文部分内容阅读
目的观察埃索美拉唑针剂对非静脉曲张性上消化道出血患者的止血效果与安全性。方法将本院收治的138例非静脉曲张性上消化道出血患者,随机分为观察组(70例)和对照组(68例),两组均给予止血、补充血容量、维持生命体征的常规治疗,在此基础上观察组加用埃索美拉唑静脉滴注,对照组加用奥美拉唑静脉滴注。给药剂量均为每次40 mg,q12 h,疗程5 d,比较两组患者治疗前后血红蛋白值、显效时间、止血时间、临床疗效及不良反应等方面的差异。结果两组患者治疗前后血红蛋白值、总有效率及不良反应发生率比较,差异无统计学意义(P>0.05)。观察组的显效时间、止血时间显著低于对照组,差异有统计学意义(P<0.05)。结论埃索美拉唑针剂用于治疗非静脉曲张性上消化道出血患者具有较好的临床疗效及安全性。
Objective To observe the efficacy and safety of esomeprazole in patients with non-variceal upper gastrointestinal bleeding. Methods One hundred and thirty-eight patients with non-variceal upper gastrointestinal bleeding admitted to our hospital were randomly divided into observation group (n = 70) and control group (n = 68). Both groups were given routine hemostasis, blood volume replacement and vital signs maintenance Treatment, on the basis of observation group plus esomeprazole intravenous infusion, the control group plus omeprazole intravenous infusion. The dosage was 40 mg every q12 h for 5 days. The difference of hemoglobin value, effective time, bleeding time, clinical efficacy and adverse reactions before and after treatment were compared between the two groups. Results There was no significant difference in hemoglobin value, total effective rate and adverse reaction between the two groups before and after treatment (P> 0.05). The observation group markedly effective time, bleeding time was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Esomeprazole injection has good clinical efficacy and safety in the treatment of patients with non-variceal upper gastrointestinal bleeding.