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本实验通过大鼠脑缺血区中生化代谢研究及离子代谢变化,证实环孢霉素A（CSA）对局部脑缺血再灌流损伤有明显的治疗作用,为CSA在治疗脑缺血再灌流损伤中的应用提供一定科学依据。1材料1.1 药物及试剂 环孢霉素 A（C62H111N11O12=1202.6）瑞士诺华制药有限公司生产,10％水合氯醛,生理盐水。1.2 动物 健康Wistar雄性大鼠100只,体重250-300g。2 方法 选用Wistar雄性大白鼠100只,体重250-300g,随机分为4组:缺血2h颈总动脉给CSA乳剂再灌流6h组;缺血2h颈总动脉给生理盐水再灌流6h组;缺血2h颈总动脉给CSA乳剂
This experiment through the rat brain ischemic biochemical metabolism and changes in ion metabolism, confirmed that cyclosporin A (CSA) on the focal cerebral ischemia-reperfusion injury has a significant therapeutic effect for the treatment of cerebral ischemia-reperfusion CSA The application of injury provides some scientific evidence. 1 Materials 1.1 Drugs and reagents Cyclosporine A (C62H111N11O12 = 1202.6) Novartis Pharmaceutical Co., Ltd. produced, 10% chloral hydrate, saline. 1.2 animal health 100 Wistar male rats, weighing 250-300g. 2 Methods 100 Wistar male rats weighing 250-300g were randomly divided into 4 groups: ischemic 2h carotid artery to CSA emulsion reperfusion 6h group; ischemia 2h common carotid artery to 6h saline reperfusion group; Blood 2h carotid artery to CSA emulsion