Nanophotocatalysts have shown great potential for degrading poly-and perfluorinated substances (PFAS).In light of the fact that most of these catalysts were studied in pure water,this study was designed to elucidate effects from common environmental factors on decomposing and defluorinating perfluorooctanoic acid (PFOA) by In2O3 nanoparticles.Results from this work demonstrated that among the seven parameters,pH,sulfate,chloride,H2O2,In2O3 dose,NOM and O2,the first four had statistically significant negative effects on PFOA degradation.Since PFOA is a strong acid,the best condition leading to the highest PFOA removal was identified for two pH ranges.When pH was between 4 and 8,the optimal condition was: pH =4.2;sulfate =5.00 mg/L;chloride =20.43 rmg/L;H2O2 =0 mmol/L.Under this condition,PFOA decomposition and defluorination were 55.22 and 23.56％,respectively.When pH was between 2 and 6,the optimal condition was: pH =2;sulfate =5.00 mg/L;chloride =27.31 mg/L;H2O2 =0 mmol/L.With this condition,the modeled PFOA decomposition was 97.59％ with a defluorination of approximately 100％.These predicted results were all confi-med by experimental data.Thus,In2O3 nanoparticles can be used for degrading PFOA in aqueous solutions.This approach works best when the target contaminated water contains low concentrations of NOM,sulfate and chloride and at a low pH.