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60年代,临床工作者已注意到海洛因成瘾者(heroin addict)易患细菌、原虫、病毒感染,并对这种现象的成因进行研究,发现除卫生习惯、营养状况等影响因素外,该类人群的免疫功能普遍低下,是一个值得重视的主要原因。其中包括丝裂原诱导的T淋巴细胞增殖能力下降、外周血T淋巴细胞数目减少以及NK细胞活性受抑等。近年来脑啡肽(enkephalin)、内啡肽(endorphin)等内源性阿片肽的免疫修饰作用的发现,以及当今世界范围内严重威胁公众健康和生命的获得
In the 1960s, clinicians noticed that heroin addict was predisposed to bacterial, protozoal and viral infections. The causes of this phenomenon were also investigated. It was found that in addition to the factors such as hygiene habits and nutritional status, People’s immune function is generally low, is a major cause for attention. Including the mitogen-induced T lymphocyte proliferation decreased, the number of peripheral blood T lymphocytes and NK cell activity suppressed and so on. The discovery of immunomodulatory effects of endogenous opioids such as enkephalin and endorphin in recent years and the serious worldwide public health and life-threatening gain