由于尿素有角质溶解和促进皮肤角质的水合作用,所以是治疗皮肤皲裂的一个常用药物.但尿素的软膏剂原处方多为以凡士林作基质;或以水油型乳剂作基质而且主药均为单纯尿素.这些处方或因尿素的吸湿性强不易研成细粉,难与凡士林类油脂性基质混匀因而制备困难;或因乳膏基质中所用乳化剂在基层医疗单位难以购买使其应用受到限 Because urea has keratolytic and promote skin hydration of keratin, it is a commonly used drug for the treatment of skin cleft palate. However, urea ointment is mostly formulated with petrolatum as the base; or water-oil emulsion as the matrix and the main drug For simple urea, these prescriptions are not easy to develop into fine powder because of the hygroscopicity of urea, are difficult to mix with the Vaseline oily matrix, and thus are difficult to prepare; or the emulsifier used in the base of the cream is difficult to purchase for use in the primary medical unit. Limited