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作者对DMH诱发大鼠大肠癌过程进行了动态研究,结果显示40只大鼠在DMH作用下,大肠粘膜显示不同程度的病变。实验第8周,大肠粘膜呈现早期增生性改变;第10～15周主要表现为粘膜轻、中度不典型增生;第18～32周除粘膜不典型增生外,大肠腺瘤和癌逐渐形成,其中检出腺瘤14个,原位癌10个,浸润性癌35个。20只对照大鼠大肠粘膜无明显病变。提示大肠癌的组织发生系经过粘膜增生→不典型增生或腺瘤→原位癌→浸润性癌的发展过程,证实不典型增生是大肠癌重要的癌前病变。
The authors performed a dynamic study on the process of DMH-induced colon cancer in rats. The results showed that 40 rats showed different degrees of lesions in the large intestine mucosa under the action of DMH. At the 8th week of the experiment, the colorectal mucosa showed early proliferative changes; in the 10th to 15th weeks, the mucosa showed mild to mild atypical hyperplasia; in the 18th to the 32nd weeks, in addition to the dysplasia of the mucosa, colorectal adenomas and cancer gradually formed. Among them, there were 14 adenomas, 10 in situ cancers, and 35 invasive cancers. There were no obvious lesions in the colon mucosa of the 20 control rats. It is suggested that the pathogenesis of colorectal cancer is through the development of mucosal hyperplasia → atypical hyperplasia or adenoma → carcinoma in situ → invasive carcinoma. It is proved that atypical hyperplasia is an important precancerous lesion of colorectal cancer.