约有10%的住院患者和2.5%的门诊患者,用药而发生有害反应。发热作为唯一的或主要的临床特征者约占这些反应的3～5%,由直接或间接用药结果引起的任何发热反应可考虑为药物热。几乎任何制剂都能涉及,但出现药物反应的确切发生率尚不明白,因此,常常不能被诊断,致使许多发热的患者不必要地遭受了大量的、有害的检查及不适当的治疗。这里主要根据医学文献中的大量病例报告和被公认的专家们的临床经验,把引起药物热常见的、少见的和极少见的有关药物列为表1:药物热的类型发热机制的现代概念认为是各种外源性的致热原(毒性的、免疫学的或传染性的)引起吞噬白细胞释放出内源性的致热原——旦白质,以致下丘脑调节体温中枢增加代谢 About 10% of hospitalized patients and 2.5% of outpatients, medication and harmful reactions. Fever, as the only or major clinical feature, accounts for about 3-5% of these reactions and any febrile reaction caused by the direct or indirect drug results can be considered as drug fever. Almost any preparation can be involved, but the exact incidence of drug reactions is not known and often can not be diagnosed, causing many feverish patients to unnecessarily suffer a large number of unwanted examinations and inappropriate treatment. Here, mainly based on a large number of case reports in medical literature and recognized experts’ clinical experience, the common, rare and rare related drugs that cause drug fever are listed in Table 1. Table 1: Modern Concepts of Drug Thermal Types of Fever It is thought that a variety of exogenous pyrogen (cytotoxic, immunological or infectious) causes phagocytic leukocytes to release endogenous pyrogen-denatured protein, so that the hypothalamus regulates the body temperature to increase metabolism