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目的 探讨外周血淋巴细胞姐妹染色单体互换(SCE)频率与非梗阻性无精子症(NOA)形成的相关性,为进行病因学研究和采取干预措施打下基础.方法 对30例NOA患者及20例已经生育的男性,按照外周血淋巴细胞SCE检测方法进行培养检测,分别计数SCE频率.结果 实验组SCE频率为8.39土1.58％;对照组为5.17±0.53％,两组对比差异非常显著(P＜0.01).结论 NOA患者的外周血淋巴细胞SCE频率明显增高,表明其染色体具有不稳定性.“,”Objective:To investigate the correlation between the frequency of sister chromatid exchange (SCE) and the formation of non-obstructive azoospermia (NOA) in peripheral blood lymphocytes,and to lay the foundation for the study of etiology and intervention.Methods:Thirty patients with NOA and 20 males who had been born were examined by SCE detection method.The frequency of SCE was counted respectively.Results:The frequency of SCE was 8.39±1.58％ in the experimental group and 5.17±0.53％ in the control group.The difference between the two groups was significant (P＜0.01).Conclusion:The frequency of SCE in peripheral blood lymphocytes of NOA patients is significantly higher,indicating that the chromosomes are unstable.