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目的：了解高原低氧分压对新生儿染色体畸变的影响；方法：常规培养新生儿脐带血（高原１６例，喀什２０例，西安３０例），制片、分带、计数观察；结果：①高原组新生儿中，发生结构改变的染色体１０例，占６２．５％，明显高于喀什组３０．０％及西安组６．６６％（Ｐ＜０．０１），喀什组又高于西安组（Ｐ＜０．０５）；②高原新生儿染色体计数观察１５９４个，发生畸变８３个，占５．２０７％，明显高于喀什组２．４０１％及西安组１．５３２％（Ｐ＜０．０１）；③高原新生儿染色体结构异常３４个，占２．１３３％，其中内复制６个，双微体１４个，碎片断１０个，着丝粒爆开１个，出现断裂或增加３个，明显高于喀什组０．８５％及西安级０．１３３％（Ｐ＜０．０１）；结论：高原新生儿染色体畸变率增高可能与低氧分压有关
Objective: To understand the effect of plateau hypoxia on neonatal chromosomal aberrations. Methods: Cord blood (16 in plateau, 20 in Kashi and 30 in Xi’an) were routinely cultured. Results: ① Among the newborn infants of plateau group, 10 structurally altered chromosomes accounted for 62.5%, significantly higher than 30.0% in Kashgar group and 6.66% in Xi’an group (P <0.01), and higher in Kashgar group than in Xi’an (P <0.05). ② The chromosome counts of 1594 newborn infants in the plateau were 83 (accounting for 5.207%), accounting for 2.401% of the cases in Kashgar group and 1.532% in the Xi’an group (P <0.05) .01). ③The chromosomal abnormalities of neonates in highland were 34, accounting for 2.133%, of which 6 were internal replicates, 14 were double microdomains, 10 were fragmented, 1 was broken by centromere, and 3 was broken or increased Which was significantly higher than 0.85% in Kashgar group and 0.133% in Xi’an (P <0.01). Conclusion: The increased chromosome aberration rate may be associated with hypoxia Pressure related