脑脊液中各种酶的测定有助于中枢神经系统疾病诊断,文献上曾提及可测定乳酸脱氢酶(LDH)、谷丙转氨基酶(GPT)和谷草转氨基酶(GOT)等。1983年mathias介绍脑脊液磷酸己糖异构酶(phosphohexose isomerase以下简称PHI)在细菌性脑膜炎时活力明显增高,诊断特异性为99.5%,敏感性达100%。由于PHI测定方法快速、简便,用来早期诊断细菌性脑膜炎,可达到及时治疗、降低病死率和并发症的目的。我院所建PHI测定方法系参 Determination of various enzymes in cerebrospinal fluid is useful for the diagnosis of central nervous system diseases. Lactate dehydrogenase (LDH), alanine aminotransferase (GPT) and transglutaminase (GOT) are mentioned in the literature. In 1983, mathias introduced cerebrospinal fluid phosphohexose isomerase (phosphohexose isomerase hereinafter referred to as PHI) in bacterial meningitis was significantly increased vitality, the diagnostic specificity of 99.5%, the sensitivity of 100%. Because PHI determination method is rapid and simple, it can be used for early diagnosis of bacterial meningitis and can achieve timely treatment and reduce the mortality and complications. PHI determination of our institute to establish the method parameters