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目的探讨艾司西酞普兰结合心理干预治疗围绝经抑郁患者的临床疗效及其对患者生活质量的影响。方法选取2014年6月~2016年1月我院收治的88例围绝经期抑郁患者作为研究对象,并随机分为对照组和研究组各44例。两组患者均给予激素替代治疗,对照组患者给予艾司西酞普兰治疗,而研究组患者则在对照组的基础上给予心理干预治疗。结果研究组患者治疗的总有效率为88.64%,显著高于对照组的70.45%,两组间差异有统计学意义(P<0.05);研究组患者治疗后的汉密尔顿抑郁量表(HAMD)、匹兹堡失眠质量指数(PSQI)和更年期症状评分(Kupperman)分别为(12.21±3.06)分、(8.54±1.46)分和(12.04±2.18)分,显著低于对照组的(16.43±2.87)分、(11.62±2.08)分和(14.64±3.21)分,两组间差异有统计学意义(P<0.05);研究组患者治疗后6个月生理功能、生理职能、躯体疼痛、总体健康、社会功能、活力、情感职能和精神健康8个维度的生活质量评分均高于对照组的,两组间差异有统计学意义(P<0.05)。结论艾司西酞普兰结合心理干预可有效改善围绝经抑郁患者的睡眠质量和抑郁状态,提高患者的生活质量,疗效确切,值得应用于临床。
Objective To investigate the clinical efficacy of escitalopram in combination with psychological intervention in the treatment of postmenopausal depression and its impact on the quality of life of patients. Methods 88 patients with perimenopausal depression treated in our hospital from June 2014 to January 2016 were selected and randomly divided into control group and study group, 44 cases each. Both groups were given hormone replacement therapy, control group patients given Escitalopram, while patients in the study group were given psychological intervention on the basis of the control group. Results The total effective rate of study group was 88.64%, which was significantly higher than that of control group (70.45%), the difference was statistically significant (P <0.05). The Hamilton Depression Rating Scale (HAMD) PSQI and Kupperman scores were (12.21 ± 3.06) points, (8.54 ± 1.46) points and (12.04 ± 2.18) points respectively, which were significantly lower than those of the control group (16.43 ± 2.87 points) (11.62 ± 2.08) points and (14.64 ± 3.21) points respectively. There was significant difference between the two groups (P <0.05). The study group’s physiological function, physical function, physical pain, general health and social function , Vitality, emotional function and mental health were all higher than those in the control group. There was significant difference between the two groups (P <0.05). Conclusion Escitalopram in combination with psychological intervention can effectively improve the quality of sleep and depression in patients with postmenopausal depression and improve the quality of life of patients with definite curative effect, which is worthy of clinical application.