The activity of South China Sea southwest monsoon (SCSSM) has direct impacts on the anomalies of important weather in Guangdong province during the raining seasons. So it is necessary to explore thoroughly the activity pattern of SCSSM and its relationship with important weather anomalies in the province. In this paper, the methods of composite analysis and correlation statistics are used to study the relationship between the onset date and intensity of SCSSM and the important weather, such as precipitation trends in Guangdong province during the annually first and second raining seasons, the timing of the annually first and last typhoon and the number of typhoons landing in Guangdong province. The results show that the rainfall is less than normal during the first raining season, but more than normal during the second one and there are more tropical cyclones landing in Guangdong province in the years of early SCSSM onset. The rainfall is more than normal during the second raining season and there are more tropical cyclones landing in Guangdong province in the years of strong SCSSM. The relationship between the SST of April - June, July - September and previous winter (December - February) and 500 hPa geopotential height and the onset date and intensity of SCSSM is analyzed. Some mechanisms between the onset dates and intensity of SCSSM and the important weather anomalies in Guangdong province are preliminarily explored. The results can be used for reference in short-term climate forecast.