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目的探讨妊娠高血压综合征(妊高征)患者血浆凝血酶调节蛋白(TM)、超敏C反应蛋白(hs-CRP)和血清可溶性血管内皮细胞黏附分子-1(sVCAM-1)在妊高征病情变化中的应用价值。方法采用双抗体夹心酶联免疫吸附法(ELISA)检测59例妊高征患者和65例正常晚期妊娠妇女的血浆TM和血清sVCAM-1水平,免疫透射比浊法检测超敏C反应蛋白(hs-CRP)的含量变化,并进行统计分析。结果妊高征患者血浆TM、hs-CRP含量和血清sVCAM-1水平均明显高于正常妊娠组(P<0.01),且随病情的加重而增高。结论血浆TM、hs-CRP和血清sVCAM-1三者联合检测可作为妊高征诊断和病情严重程度观察的实验室辅助指标。
Objective To investigate the changes of plasma thrombomodulin (TM), high-sensitivity C-reactive protein (hs-CRP) and serum soluble vascular endothelial cell adhesion molecule-1 (sVCAM-1) in patients with pregnancy induced hypertension (PIH) The value of the application of changes in the disease. Methods The levels of serum TM and serum sVCAM-1 in 59 PIH patients and 65 normal pregnant women were measured by ELISA. The levels of hs -CRP) content changes, and statistical analysis. Results The levels of plasma TM, hs-CRP and serum sVCAM-1 in patients with PIH were significantly higher than those in normal pregnancy (P <0.01), and increased with the severity of PIH. Conclusion The combined detection of plasma TM, hs-CRP and serum sVCAM-1 may be used as a laboratory auxiliary index for the diagnosis and severity of pregnancy-induced hypertension.