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内皮损害似是皮肌炎的免疫病理学特征之一,即使在疾病的早期阶段亦然。基于这一原因,不论病人有无明显的皮肤损害,目前把毛细血管损害视为诊断皮肌炎的一项重要指标。本文研究了皮肌炎病人的抗内皮细胞抗体的阳性率和特点,以评价其临床意义以及在发病方面的作用。病人和方法 18例皮肌炎病人均经活检证实,并有临床和实验室检查方面的特殊表现。其中女12例,男6例,平均年龄51岁。各例的肌肉活检标本均有炎症和坏死改变,并有明显的毛细血管损害。另检查了22例其它类型的肌病病人和50名年龄和性别相匹配的健康供血者。用酶联免疫吸附分析法检测抗内皮细胞的 IgG 和
Endothelial damage appears to be one of the immunopathological features of dermatomyositis, even in the early stages of the disease. For this reason, capillary damage is currently considered as an important indicator of dermatomyositis, regardless of whether the patient has any significant skin lesions. In this paper, the anti-endothelial cell antibody positive rate and characteristics of patients with dermatomyositis were studied to evaluate its clinical significance and its role in the pathogenesis. Patients and Methods Eighteen patients with dermatomyositis were confirmed biopsy with special clinical and laboratory findings. Among them, there were 12 females and 6 males, with an average age of 51 years. Each case of muscle biopsy specimens have changes in inflammation and necrosis, and significant damage to the capillaries. Another study examined 22 other types of myopathy patients and 50 age and sex matched healthy blood donors. Anti-endothelial cell IgG and IgG were detected by enzyme-linked immunosorbent assay