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目的:研究葛根总黄酮分散片在大鼠体内的药代动力学特征及生物利用度,并与市售愈风宁心片进行比较。方法:大鼠灌胃给药葛根总黄酮分散片(受试制剂)及市售片(参比制剂)混悬液,采用HPLC测定给药后各时间点的血药浓度,用统计软件计算主要药代动力学参数。结果:分散片与市售片的C max分别为(20.21±0.18),(9.90±0.25)mg·L-1;分散片的T max=(0.50±0.03)h,市售片T max=(1.09±0.02)h;分散片相对于市售片的生物利用度为182.68%。结论:葛根总黄酮分散片吸收快,起效时间明显提前,生物利用度明显优于市售片。
OBJECTIVE: To study the pharmacokinetics and bioavailability of Pueraria total flavonoids dispersible tablets in rats, and to compare with the commercial Feng-Ning tablets. Methods: The rats were intragastrically administered Puerarin total flavonoids dispersible tablets (test preparations) and commercially available tablets (reference preparation) suspension, HPLC determination of plasma concentrations at various time points after administration, using statistical software to calculate the main Pharmacokinetic parameters. Results: The C max values of the dispersible tablets and the commercial tablets were (20.21 ± 0.18) and (9.90 ± 0.25) mg · L -1, respectively. The T max of the dispersible tablets was (0.50 ± 0.03) 1.09 ± 0.02) h; the bioavailability of dispersible tablets relative to the commercial tablets was 182.68%. Conclusion: Pueraria total flavonoids dispersible tablets absorbed quickly, the onset time was significantly earlier, bioavailability was significantly better than the commercially available tablets.