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瘦素是一种主要由脂肪组织产生的蛋白质,它以游离形式或与瘦素结合蛋白结合的形式循环于血中。它是一种多效分子,有多种生物学活性,包括调节能量平衡、神经内分泌、免疫功能、血细胞生成等。瘦素受体(ob-R)存在于几乎所有组织中。瘦素就是通过激活中枢神经系统和外周组织的特异性受体发挥作用的。瘦素和慢性阻塞性肺疾病(COPD)有着密切的关系,它与COPD患者的营养不良和炎症状态有关。细胞因子-瘦素的联合作用可能是COPD患者极度营养不良且对营养支持反应差的原因。瘦素除了参与COPD的全身性炎症反应外还参与了气道局部炎症反应。瘦素影响COPD的发生发展和预后,是病情评价的指标。
Leptin is a protein that is produced mainly by adipose tissue and circulates in the blood either in free form or in combination with leptin-binding proteins. It is a pleiotropic molecule with a variety of biological activities including regulation of energy balance, neuroendocrine, immune function, hematopoiesis, and the like. Leptin receptor (ob-R) is present in almost all tissues. Leptin acts by activating specific receptors on the central nervous system and peripheral tissues. Leptin is associated with chronic obstructive pulmonary disease (COPD), which is associated with malnutrition and inflammation in COPD patients. The combined effect of cytokine-leptin may be the cause of extreme malnutrition in COPD patients and poor response to nutritional support. Leptin is involved in the local inflammatory response of the airways in addition to its systemic inflammatory response to COPD. Leptin affects the occurrence and development of COPD and prognosis, is an indicator of disease evaluation.