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患者男性,50岁,5年前发现两腋下皮肤轻度增厚,肩部活动受限,以后皮肤逐渐增厚,渐累及躯干、头、颈、两上肢近端,最后累及两臂远端和双手,阴部皮肤受累使阴茎勃起困难。吞咽困难3年,手指对冷敏感2年,指节苍白、疼痛,1年多来指趾出现持续的灼痛,日趋严重,伴指异常感,持物不稳,就诊后6个月来有中度呼吸困难。3年来有不稳定高血压病史。体检见弥漫性的皮肤变厚伴皮下组织受累,大片皮肤与深部组织粘在一起,头、舌活动及张口、睁眼均明显受限,躯干和两上肢活
Male, 50 years old, 5 years ago found that the two underarm skin mild thickening, limited shoulder activity, after the gradual thickening of the skin, gradually and the trunk, head, neck, proximal upper limbs, and finally involving the distal arms And hands, genitals affected the penile erection difficult. Dysphagia 3 years, fingers sensitive to cold for 2 years, knuckles pale, pain, more than a year toe sustained burning sensation, growing serious, with anomalies, persistent instability, 6 months after treatment in the middle Degree of breathing difficulties. 3 years history of unstable hypertension. Physical examination showed diffuse thickening of the skin with subcutaneous tissue involvement, large skin and deep tissue stick together, head and tongue activities and mouth, eyes were significantly limited, the trunk and upper limb live