我院于1995年5月研制氯硝酊，外用治疗寻常痤疮100例，总有效率达98％，其中治疗愈88例，显效10例。患者病程最长12年，最短3个月，均接受过其他药物治疗，疗效不理想。为控制氮硝配的产品质量，采用酸性偶合显色剂，建立了直接测定制剂中氯霉素和甲硝唑含量的方法，现将氯硝酊 Our hospital in May 1995 developed clonidine, topical 100 cases of acne vulgaris, the total effective rate of 98%, of which 88 cases of treatment, markedly effective in 10 cases. Patients with a maximum duration of 12 years, the shortest 3 months, have received other drug treatment, the effect is not satisfactory. In order to control the quality of products with nitrogen and nitrate, a method of directly determining the content of chloramphenicol and metronidazole in the preparation was established by using acidic coupling reagent. Now,