J.Am.Chem.Soc.2016,138,12348~12351铜催化末端炔烃交叉偶联(Glaser-Hay reaction)是《有机化学》教科书中的一个基本反应,其生成1,3-二炔类化合物,在有机合成及材料科学中应用广泛,但大量实验结果和理论研究表明,当该反应使用两种不同炔烃时,两种自偶联产物则占多数,不能选择性地合成不对称1,3-二炔类化合物,由此限制了其在有机合成特别是天然产物和功能 J. Am. Chem. Soc. 2016, 138, 12348-12351 The copper-catalyzed Glaser-Hay reaction is a fundamental reaction in the Organic Chemistry textbook that produces 1,3-dioxoles Compounds are widely used in organic synthesis and materials science. However, a large number of experimental and theoretical studies show that when two different alkynes are used in the reaction, the two products are mostly self-coupled and can not selectively synthesize asymmetric 1 , 3-diyne compounds, thus limiting their use in organic synthesis, especially natural products and functions