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目的:探讨微创穿刺粉碎技术合并大剂量纳洛酮治疗高血压性脑出血,提高患者的生存质量,降低重残率及死亡率。方法:将110例高血压性脑出血患者分成两组:A组(微创治疗+大剂量纳洛酮)B组(微创治疗),A组77例,B组33例,两组均采用微创穿刺粉碎技术清除脑内血肿,A组在手术前静脉注射纳洛酮4mg,术后纳洛酮10mg/d~20mg/d,维持静点共一周,观察两组疗效。结果:(1)存活患者中日常生活能力(ADL)A组明显优于B组(P<0.01)(2)A组死亡率(12.98%)及重残率(5.97%)均明显低于B组(21.21%、19.23%)(P<0.01、P<0.01)。结论:微创穿刺粉碎技术合并大剂量纳洛酮治疗高血压性脑出血较单纯微创治疗效果好,能明显提高患者的生存质量,降低重残率及死亡率。
Objective: To explore the minimally invasive puncture and smash technology combined with high-dose naloxone in the treatment of hypertensive intracerebral hemorrhage, improve the quality of life of patients, reduce severe disability and mortality. Methods: 110 cases of hypertensive intracerebral hemorrhage were divided into two groups: group A (minimally invasive treatment + high-dose naloxone) group B (minimally invasive treatment), group A 77 cases, group B 33 cases, both groups were used Minimally invasive puncture technique to remove intracerebral hematoma, A group before the intravenous injection of naloxone 4mg, postoperative naloxone 10mg / d ~ 20mg / d, to maintain the static point for a total of two weeks to observe the curative effect. (2) The death rate (12.98%) and severe disability (5.97%) in group A were significantly lower than that in group B (21.21%, 19.23%) (P <0.01, P <0.01). Conclusion: The minimally invasive puncture and smash technique combined with high-dose naloxone in treatment of hypertensive intracerebral hemorrhage is more effective than simple and minimally invasive treatment, which can significantly improve the quality of life of patients and reduce the rate of severe disability and mortality.